A solitary version of Frankenstein wanders into the dark and bustling streets of Chicago during the 1930s, searching for a way to end his deep loneliness. Hoping to find someone who can understand his strange existence, he approaches the brilliant and unconventional scientist Dr. Euphronious. Frankenstein asks the scientist to help him create a companion, someone who could share his life and ease his isolation. With daring experiments and controversial methods, the two manage to bring a murdered young woman back to life, giving birth to a new being known as The Bride. However, the result of their experiment is far more complicated than they expected. As The Bride begins to discover the world and her own identity, unexpected consequences unfold, changing the lives of everyone involved and leading to events that neither Frankenstein nor Dr. Euphronious could have predicted.