When her mother suddenly disappears without a trace, Enola Holmes sets out on a mission to uncover the truth. As the intelligent and determined younger sister of Sherlock Holmes, she refuses to sit back and let others take control of the investigation. Following a trail of clues, Enola becomes entangled in a dangerous mystery involving secrets, deception, and a far reaching conspiracy. While trying to stay one step ahead of those who seek to stop her, she relies on her wit, courage, and sharp instincts to solve the case. Along the way, Enola proves that she is a talented detective in her own right and capable of taking on challenges that even the most experienced investigators would find difficult.